Telomeres were isolated from chicken erythrocyte nuclei following restriction endonuclease treatment, and imaged by transmission EM after uranyl acetate negative staining. Like its DNA counterpart, telomeric chromatin has have a looped conformation, which likely aids in protection from the rapid degradation that occurs with free DNA ends.
The image was recorded with a FEI Tecnai 12 TEM at 100KV and recorded on a TVIPS 2048x2048 CCD with 2x binning. See Nikitina T, Woodcock CL. 2004. Closed chromatin loops at the ends of chromosomes. J Cell Biol.166:161-5.
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