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*CIL – Cell Image Library accession number. Please use this to reference an image.

CIL:39075*  Cite 

Scanning electron micrograph of normal red blood cell (background, colored red) and red blood cell affected by sickle-cell anaemia (foreground, colored tan). Sickle-cell anemia is a blood disease that causes the cell to form a characteristic sickle-shape. This change in shape affects the cell's ability to carry haemoglobin (an iron-rich protein that gives red blood cells their colour and allows for efficient oxygen transport). Sickle-cell anemia results in abnormal blood flow and a reduction in the red blood cell count. It is a genetic disorder that results when an individual has two copies of the relevant gene. It is common in countries in which malaria is prevalent, as carrying one copy of the sickle-cell gene provides advantageous resistance to malaria and is known as 'sickle-cell trait'.

Technical Details

B0007446 Wellcome Image Award winner 2009 Scanning electron micrograph. Wellcome Images available under the following creative commons usage

Biological Sources
Cell Type
blood cell
Cellular Component
cell surface
Biological Context
Human Disease
sickle cell anemia
wellcome images
Digital Object Identifier (DOI)
Archival Resource Key (ARK)
Image Type
recorded image
Image Mode
scanning electron microscopy (SEM)
Parameters Imaged
elastic scattering of electrons
Source of Contrast
differences in deposition of metal shadow
Visualization Methods
visualization of contiguous regions
Processing History
Sample Preparation
chemically fixed tissue
Relation To Intact Cell
whole mounted tissue
Spatial Axis Image Size Pixel Size
X 737px ——
Y 576px ——