Transmission electron micrograph of a representative untreated wildtype prototrophic cell (derived from S288c). A large vacuole containing multiple electron-lucent inclusions is present. (8,000X). A similar cell treated with sertraline is available as CIL 40431.
This group of images contains representative whole-cell images and high-magnification zooms of organelle structures of interest. All cells were grown in liquid rich media (YPD pH6.5) at 30C with aerated shaking, and cultures were sampled in mid-logarithmic phase. Treated cells were exposed to 60µM antidepressant sertraline (Zoloft®) for 45 minutes.
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