Transmission electron micrograph of a representative sertraline-treated vma9 mutant cell. VMA9 encodes a subunit of the vacuolar-type H+-ATPase (V-ATPase). Sertraline treatment is associated with an increase in electron lucency in vacuolar lumens. (8,000X). An untreated control image of the same mutant is available as CIL: 40450.
This group of images contains representative whole-cell images and high-magnification zooms of organelle structures of interest. All cells were grown in liquid rich media (YPD pH6.5) at 30C with aerated shaking, and cultures were sampled in mid-logarithmic phase. Treated cells were exposed to 60µM antidepressant sertraline (Zoloft®) for 45 minutes.
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