Transmission electron micrograph of a representative untreated vma9 mutant cell. VMA9 encodes a subunit of the vacuolar-type H+-ATPase (V-ATPase). vma9 mutant cells contain non-spherical vacuoles at a higher rate than wildtype cells. (8,000X). A sertraline-treated image of the same mutant is available as CIL: 40449.
This group of images contains representative whole-cell images and high-magnification zooms of organelle structures of interest. All cells were grown in liquid rich media (YPD pH6.5) at 30C with aerated shaking, and cultures were sampled in mid-logarithmic phase. Treated cells were exposed to 60µM antidepressant sertraline (Zoloft®) for 45 minutes.
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