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Licensing
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*CIL – Cell Image Library accession number. Please use this to reference an image.

CIL:47059*  Cite 
Description

Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain tumor in humans. Here we show that gliomas can originate from differentiated cells in the central nervous system (CNS), including cortical neurons. Transduction by oncogenic lentiviral vectors of neural stem cells (NSCs), astrocytes, or even mature neurons in the brains of mice can give rise to malignant gliomas. All the tumors, irrespective of the site of lentiviral vector injection (the initiating population), shared common features of high expression of stem or progenitor markers and low expression of differentiation markers. Microarray analysis revealed that tumors of astrocytic and neuronal origin match the mesenchymal GBM subtype. We propose that most differentiated cells in the CNS upon defined genetic alterations undergo dedifferentiation to generate a NSC or progenitor state to initiate and maintain the tumor progression, as well as to give rise to the heterogeneous populations observed in malignant gliomas.

Biological Sources
NCBI Organism Classification
Mus musculus castaneus
Attribution
Names
Inder Verma
Dinorah Friedmann-Morvinski
Eric Bushong
Mark Ellisman
Link
CCDB 8171
Citation
Digital Object Identifier (DOI)
doi:10.7295/W9CIL47059
Archival Resource Key (ARK)
ark:/b7295/w9cil47059
Grouping This image is part of a group.
Sample Preparation
Methods
formaldehyde fixed tissue
Relation To Intact Cell
vibratome-sectioned tissue
Dimensions
Spatial Axis Image Size Pixel Size
X 512px 0.36µm
Y 512px 0.36µm