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CIL:54427*  Cite 

Pathology load assessment of de-identified, human, post-mortem Alzheimer's disease and age-matched non-symptomatic donor prefrontal cortex brain tissue. We used these imaging data to inform donor stratification when we generated a large single nuclei RNA sequencing (snRNA-seq) dataset. Given we generated both imaging and snRNA-seq datasets the same location/piece of tissue for each donor, this gives us an unprecedented platform to evaluate cell type/subpopulation transcriptomes and relate them directly to their respective tissue microenvironments.

Technical Details

5 um sections of FFPE prefrontal cortex tissue from post-mortem, human non-symptomatic donor labeled for hematoxylin and eosin

Biological Sources
NCBI Organism Classification
Homo sapiens
Biological Context
Biological Process
Aged non-symptomatic control patient
Jessica S. Sadick
Shane A. Liddelow
Digital Object Identifier (DOI)
Archival Resource Key (ARK)
Grouping This image is part of a group.
Image Mode
bright-field microscopy
Visualization Methods
hematoxylin and eosin