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We examined the structural organization of cytoskeletal components and membrane systems in neurons of well preserved biopsy material from Alzheimer’s disease (AD). Information was obtained from thin sectioned material using conventional electron microscopy and from thick sections with the high voltage electron microscope. Stereo viewing and computer assisted serial reconstruction techniques were employed to visualize three-dimensional relationships among cytoplasmic components of cortical neurons.

Technical Details

2D survey of cerebral cortex.

Biological Sources
NCBI Organism Classification
Homo sapiens
Cell Type
pyramidal cell
neuron of cerebral cortex
Cellular Component
neuronal cell body
Biological Context
Human Disease
Alzheimer's disease
Mark Ellisman
Tom Deerinck
Matthew Madany
Image Type
EM tomogram
Image Mode
SEM survey